2021 Mid-American Conference Leaders Rushing Defense - Games in August/September Only through 01/10/2022
| Name | G | Att | Yards | Avg. | TD | Att/G | Yards/G | |
|---|---|---|---|---|---|---|---|---|
| 1 | Central Michigan | 4 | 118 | 391 | 3.31 | 4 | 29.50 | 97.75 |
| 2 | Western Michigan | 4 | 123 | 498 | 4.05 | 3 | 30.75 | 124.50 |
| 3 | Toledo | 4 | 165 | 610 | 3.70 | 1 | 41.25 | 152.50 |
| 4 | Buffalo | 4 | 163 | 667 | 4.09 | 8 | 40.75 | 166.75 |
| 5 | Bowling Green | 4 | 178 | 696 | 3.91 | 8 | 44.50 | 174.00 |
| 6 | Ball State | 4 | 155 | 759 | 4.90 | 7 | 38.75 | 189.75 |
| 6 | Akron | 4 | 132 | 759 | 5.75 | 13 | 33.00 | 189.75 |
| 8 | Eastern Michigan | 4 | 160 | 778 | 4.86 | 8 | 40.00 | 194.50 |
| 9 | Kent State | 4 | 145 | 789 | 5.44 | 8 | 36.25 | 197.25 |
| 10 | Miami (Ohio) | 4 | 178 | 844 | 4.74 | 8 | 44.50 | 211.00 |
| 11 | Northern Illinois | 4 | 174 | 960 | 5.52 | 16 | 43.50 | 240.00 |
| 12 | Ohio | 4 | 189 | 1134 | 6.00 | 13 | 47.25 | 283.50 |