2021 Mid-American Conference Leaders Rushing Defense - Games vs. Ranked Teams Only (AP Poll) through 01/10/2022
| Name | G | Att | Yards | Avg. | TD | Att/G | Yards/G | |
|---|---|---|---|---|---|---|---|---|
| 1 | Toledo | 1 | 39 | 132 | 3.38 | 1 | 39.00 | 132.00 |
| 2 | Western Michigan | 2 | 67 | 410 | 6.12 | 3 | 33.50 | 205.00 |
| 3 | Kent State | 1 | 38 | 206 | 5.42 | 3 | 38.00 | 206.00 |
| 4 | Akron | 1 | 35 | 237 | 6.77 | 5 | 35.00 | 237.00 |
| 5 | Miami (Ohio) | 1 | 31 | 247 | 7.97 | 3 | 31.00 | 247.00 |
| 6 | Ohio | 1 | 49 | 310 | 6.33 | 5 | 49.00 | 310.00 |
| 7 | Northern Illinois | 1 | 48 | 373 | 7.77 | 8 | 48.00 | 373.00 |