2021 Atlantic Coast Conference Leaders Total Defense - Games vs. Non-Conference Teams Only through 01/10/2022
| Name | G | Rush Yards | Pass Yards | Plays | Total Yards | Yards/Play | Yards/G | |
|---|---|---|---|---|---|---|---|---|
| 1 | Clemson | 5 | 312 | 754 | 302 | 1066 | 3.53 | 213.2 |
| 2 | Syracuse | 4 | 341 | 704 | 249 | 1045 | 4.20 | 261.3 |
| 3 | Boston College | 4 | 392 | 762 | 238 | 1154 | 4.85 | 288.5 |
| 4 | North Carolina State | 4 | 357 | 906 | 261 | 1263 | 4.84 | 315.8 |
| 5 | Pittsburgh | 5 | 494 | 1176 | 348 | 1670 | 4.80 | 334.0 |
| 6 | Florida State | 4 | 424 | 955 | 285 | 1379 | 4.84 | 344.8 |
| 7 | Virginia Tech | 5 | 792 | 1049 | 317 | 1841 | 5.81 | 368.2 |
| 8 | Wake Forest | 4 | 813 | 666 | 292 | 1479 | 5.07 | 369.8 |
| 8 | Miami (Florida) | 4 | 496 | 983 | 285 | 1479 | 5.19 | 369.8 |
| 10 | Georgia Tech | 4 | 739 | 804 | 232 | 1543 | 6.65 | 385.8 |
| 11 | North Carolina | 4 | 978 | 655 | 264 | 1633 | 6.19 | 408.3 |
| 12 | Virginia | 4 | 844 | 833 | 269 | 1677 | 6.23 | 419.3 |
| 13 | Duke | 4 | 723 | 963 | 282 | 1686 | 5.98 | 421.5 |
| 14 | Louisville | 5 | 1005 | 1122 | 321 | 2127 | 6.63 | 425.4 |