2016 Conference USA Leaders Total Defense - Games vs. FBS Power 5 Conference Teams Only through 01/09/2017
| Name | G | Rush Yards | Pass Yards | Plays | Total Yards | Yards/Play | Yards/G | |
|---|---|---|---|---|---|---|---|---|
| 1 | UTEP | 1 | 171 | 245 | 75 | 416 | 5.55 | 416.0 |
| 2 | Western Kentucky | 2 | 234 | 630 | 152 | 864 | 5.68 | 432.0 |
| 3 | Southern Mississippi | 2 | 279 | 589 | 92 | 868 | 9.43 | 434.0 |
| 4 | UTSA | 2 | 388 | 512 | 149 | 900 | 6.04 | 450.0 |
| 5 | Old Dominion | 1 | 158 | 312 | 71 | 470 | 6.62 | 470.0 |
| 6 | North Texas | 1 | 255 | 216 | 72 | 471 | 6.54 | 471.0 |
| 7 | Louisiana Tech | 2 | 302 | 661 | 148 | 963 | 6.51 | 481.5 |
| 7 | Florida International | 2 | 485 | 478 | 146 | 963 | 6.60 | 481.5 |
| 9 | Florida Atlantic | 2 | 615 | 350 | 142 | 965 | 6.80 | 482.5 |
| 10 | Middle Tennessee | 2 | 579 | 394 | 177 | 973 | 5.50 | 486.5 |
| 11 | Rice | 2 | 669 | 503 | 157 | 1172 | 7.46 | 586.0 |
| 12 | Marshall | 2 | 525 | 697 | 150 | 1222 | 8.15 | 611.0 |
| 13 | Charlotte | 1 | 272 | 391 | 70 | 663 | 9.47 | 663.0 |