2021 Conference USA Leaders Rushing Defense - When Winning By 15+ Pts through 01/10/2022
| Name | G | Att | Yards | Avg. | TD | Long | 1st | 10+ | 20+ | |
|---|---|---|---|---|---|---|---|---|---|---|
| 1 | Southern Mississippi | 2 | 15 | -15 | -1.00 | 0 | 8 | 1 | 0 | 0 |
| 2 | Rice | 1 | 15 | 43 | 2.87 | 3 | 11 | 1 | 1 | 0 |
| 3 | Florida International | 2 | 33 | 85 | 2.58 | 0 | 12 | 6 | 1 | 0 |
| 4 | Florida Atlantic | 5 | 37 | 104 | 2.81 | 1 | 45 | 4 | 2 | 1 |
| 4 | Charlotte | 2 | 31 | 104 | 3.35 | 1 | 25 | 7 | 4 | 1 |
| 6 | Old Dominion | 3 | 45 | 109 | 2.42 | 0 | 19 | 7 | 3 | 0 |
| 7 | Louisiana Tech | 3 | 38 | 141 | 3.71 | 3 | 14 | 11 | 7 | 0 |
| 8 | Middle Tennessee | 5 | 66 | 157 | 2.38 | 4 | 21 | 12 | 5 | 1 |
| 9 | UTSA | 6 | 108 | 181 | 1.68 | 1 | 14 | 21 | 10 | 0 |
| 10 | UAB | 7 | 81 | 198 | 2.44 | 1 | 17 | 12 | 4 | 0 |
| 11 | North Texas | 4 | 61 | 228 | 3.74 | 0 | 56 | 13 | 7 | 2 |
| 12 | UTEP | 6 | 48 | 291 | 6.06 | 3 | 68 | 13 | 10 | 3 |
| 13 | Western Kentucky | 9 | 159 | 620 | 3.90 | 9 | 31 | 36 | 20 | 3 |
| 14 | Marshall | 7 | 158 | 703 | 4.45 | 5 | 75 | 40 | 20 | 3 |
| 1st: First Downs; 10+: Rush attempts of 10 or more yards; 20+: Rush attempts of 20 or more yards | ||||||||||