2021 Conference USA Leaders Rushing Defense - When Losing By 15+ Pts through 01/10/2022
| Name | G | Att | Yards | Avg. | TD | Long | 1st | 10+ | 20+ | |
|---|---|---|---|---|---|---|---|---|---|---|
| 1 | Marshall | 3 | 20 | 67 | 3.35 | 0 | 28 | 5 | 2 | 1 |
| 2 | UTSA | 2 | 36 | 153 | 4.25 | 2 | 42 | 10 | 5 | 1 |
| 3 | Western Kentucky | 2 | 47 | 180 | 3.83 | 2 | 17 | 9 | 7 | 0 |
| 4 | UAB | 2 | 43 | 193 | 4.49 | 2 | 21 | 13 | 8 | 2 |
| 5 | Old Dominion | 4 | 74 | 195 | 2.64 | 2 | 20 | 12 | 5 | 1 |
| 6 | Louisiana Tech | 3 | 42 | 196 | 4.67 | 2 | 47 | 7 | 6 | 3 |
| 7 | Middle Tennessee | 4 | 60 | 245 | 4.08 | 3 | 33 | 9 | 7 | 3 |
| 8 | Charlotte | 4 | 49 | 253 | 5.16 | 4 | 60 | 12 | 8 | 4 |
| 9 | UTEP | 4 | 69 | 277 | 4.01 | 2 | 30 | 15 | 10 | 4 |
| 10 | North Texas | 5 | 97 | 374 | 3.86 | 5 | 85 | 15 | 9 | 4 |
| 11 | Florida Atlantic | 5 | 104 | 458 | 4.40 | 4 | 73 | 22 | 14 | 3 |
| 12 | Southern Mississippi | 7 | 101 | 480 | 4.75 | 3 | 55 | 21 | 15 | 6 |
| 13 | Rice | 4 | 91 | 588 | 6.46 | 6 | 65 | 28 | 17 | 7 |
| 14 | Florida International | 9 | 160 | 971 | 6.07 | 13 | 57 | 52 | 31 | 7 |
| 1st: First Downs; 10+: Rush attempts of 10 or more yards; 20+: Rush attempts of 20 or more yards | ||||||||||