2021 Conference USA Leaders Rushing Defense - Games in November Only through 01/10/2022
| Name | G | Att | Yards | Avg. | TD | Att/G | Yards/G | |
|---|---|---|---|---|---|---|---|---|
| 1 | Middle Tennessee | 4 | 111 | 323 | 2.91 | 3 | 27.75 | 80.75 |
| 2 | UAB | 4 | 128 | 338 | 2.64 | 6 | 32.00 | 84.50 |
| 3 | Rice | 4 | 121 | 396 | 3.27 | 6 | 30.25 | 99.00 |
| 4 | Western Kentucky | 4 | 136 | 398 | 2.93 | 4 | 34.00 | 99.50 |
| 5 | North Texas | 4 | 121 | 480 | 3.97 | 2 | 30.25 | 120.00 |
| 6 | Florida Atlantic | 4 | 124 | 488 | 3.94 | 5 | 31.00 | 122.00 |
| 7 | Old Dominion | 4 | 139 | 531 | 3.82 | 3 | 34.75 | 132.75 |
| 8 | Marshall | 4 | 159 | 617 | 3.88 | 3 | 39.75 | 154.25 |
| 9 | Louisiana Tech | 4 | 153 | 762 | 4.98 | 12 | 38.25 | 190.50 |
| 10 | Southern Mississippi | 4 | 155 | 774 | 4.99 | 5 | 38.75 | 193.50 |
| 11 | UTSA | 4 | 178 | 824 | 4.63 | 9 | 44.50 | 206.00 |
| 12 | Charlotte | 4 | 160 | 838 | 5.24 | 16 | 40.00 | 209.50 |
| 13 | UTEP | 4 | 166 | 839 | 5.05 | 10 | 41.50 | 209.75 |
| 14 | Florida International | 4 | 188 | 1243 | 6.61 | 14 | 47.00 | 310.75 |