2021 Conference USA Leaders Rushing Defense - Games in December/January Only through 01/10/2022
| Name | G | Att | Yards | Avg. | TD | Att/G | Yards/G | |
|---|---|---|---|---|---|---|---|---|
| 1 | UTSA | 2 | 56 | 147 | 2.63 | 3 | 28.00 | 73.50 |
| 2 | UTEP | 1 | 35 | 181 | 5.17 | 2 | 35.00 | 181.00 |
| 3 | UAB | 1 | 35 | 199 | 5.69 | 4 | 35.00 | 199.00 |
| 4 | North Texas | 1 | 47 | 203 | 4.32 | 1 | 47.00 | 203.00 |
| 5 | Marshall | 1 | 51 | 220 | 4.31 | 3 | 51.00 | 220.00 |
| 6 | Middle Tennessee | 1 | 32 | 235 | 7.34 | 1 | 32.00 | 235.00 |
| 7 | Old Dominion | 1 | 65 | 244 | 3.75 | 1 | 65.00 | 244.00 |
| 8 | Western Kentucky | 2 | 97 | 565 | 5.82 | 6 | 48.50 | 282.50 |