2021 Conference USA Leaders Passes Defended - Games vs. Non-Conference Teams Only through 01/10/2022
| Name | G | Int. | Passes Broken Up | Passes Defended | Passes Defended/G | |
|---|---|---|---|---|---|---|
| 1 | Middle Tennessee | 5 | 7 | 21 | 28 | 5.60 |
| 2 | UAB | 5 | 3 | 20 | 23 | 4.60 |
| 3 | Western Kentucky | 5 | 3 | 19 | 22 | 4.40 |
| 4 | UTEP | 5 | 2 | 18 | 20 | 4.00 |
| 5 | Florida Atlantic | 4 | 5 | 13 | 18 | 4.50 |
| 6 | Marshall | 5 | 3 | 14 | 17 | 3.40 |
| 7 | Florida International | 4 | 1 | 15 | 16 | 4.00 |
| 8 | Louisiana Tech | 4 | 3 | 11 | 14 | 3.50 |
| 8 | Rice | 4 | 3 | 11 | 14 | 3.50 |
| 8 | Charlotte | 4 | 1 | 13 | 14 | 3.50 |
| 8 | UTSA | 5 | 2 | 12 | 14 | 2.80 |
| 12 | Southern Mississippi | 4 | 2 | 10 | 12 | 3.00 |
| 13 | Old Dominion | 5 | 0 | 10 | 10 | 2.00 |
| 14 | North Texas | 5 | 3 | 6 | 9 | 1.80 |