2021 Conference USA Leaders Passes Defended - Games Won Only through 01/10/2022
| Name | G | Int. | Passes Broken Up | Passes Defended | Passes Defended/G | |
|---|---|---|---|---|---|---|
| 1 | Western Kentucky | 9 | 20 | 49 | 69 | 7.67 |
| 2 | UTSA | 12 | 12 | 40 | 52 | 4.33 |
| 3 | UAB | 9 | 9 | 40 | 49 | 5.44 |
| 4 | Middle Tennessee | 7 | 12 | 34 | 46 | 6.57 |
| 5 | UTEP | 7 | 7 | 33 | 40 | 5.71 |
| 6 | Florida Atlantic | 5 | 8 | 29 | 37 | 7.40 |
| 7 | Rice | 4 | 9 | 21 | 30 | 7.50 |
| 8 | Old Dominion | 6 | 4 | 21 | 25 | 4.17 |
| 9 | North Texas | 6 | 3 | 21 | 24 | 4.00 |
| 10 | Marshall | 7 | 8 | 15 | 23 | 3.29 |
| 11 | Charlotte | 5 | 2 | 20 | 22 | 4.40 |
| 12 | Southern Mississippi | 3 | 5 | 10 | 15 | 5.00 |
| 13 | Louisiana Tech | 3 | 3 | 10 | 13 | 4.33 |
| 14 | Florida International | 1 | 0 | 3 | 3 | 3.00 |