2021 Conference USA Leaders Passes Defended - Games vs. FBS Teams With Winning Record Only through 01/10/2022
| Name | G | Int. | Passes Broken Up | Passes Defended | Passes Defended/G | |
|---|---|---|---|---|---|---|
| 1 | Western Kentucky | 7 | 10 | 25 | 35 | 5.00 |
| 2 | Middle Tennessee | 5 | 8 | 24 | 32 | 6.40 |
| 3 | Old Dominion | 7 | 4 | 26 | 30 | 4.29 |
| 4 | UTSA | 6 | 5 | 24 | 29 | 4.83 |
| 5 | Marshall | 6 | 2 | 26 | 28 | 4.67 |
| 6 | Florida Atlantic | 6 | 5 | 22 | 27 | 4.50 |
| 7 | Rice | 6 | 5 | 21 | 26 | 4.33 |
| 8 | North Texas | 7 | 4 | 16 | 20 | 2.86 |
| 9 | UAB | 6 | 3 | 16 | 19 | 3.17 |
| 10 | Louisiana Tech | 6 | 3 | 15 | 18 | 3.00 |
| 11 | Southern Mississippi | 5 | 5 | 10 | 15 | 3.00 |
| 11 | Florida International | 5 | 1 | 14 | 15 | 3.00 |
| 13 | UTEP | 4 | 1 | 12 | 13 | 3.25 |
| 14 | Charlotte | 4 | 3 | 7 | 10 | 2.50 |