2021 Conference USA Leaders Passes Defended - Games in November Only through 01/10/2022
| Name | G | Int. | Passes Broken Up | Passes Defended | Passes Defended/G | |
|---|---|---|---|---|---|---|
| 1 | Western Kentucky | 4 | 14 | 20 | 34 | 8.50 |
| 2 | Middle Tennessee | 4 | 3 | 20 | 23 | 5.75 |
| 3 | UAB | 4 | 2 | 19 | 21 | 5.25 |
| 4 | Southern Mississippi | 4 | 7 | 13 | 20 | 5.00 |
| 4 | Rice | 4 | 6 | 14 | 20 | 5.00 |
| 6 | Old Dominion | 4 | 4 | 15 | 19 | 4.75 |
| 6 | Marshall | 4 | 1 | 18 | 19 | 4.75 |
| 6 | UTEP | 4 | 1 | 18 | 19 | 4.75 |
| 9 | Florida Atlantic | 4 | 3 | 14 | 17 | 4.25 |
| 9 | North Texas | 4 | 2 | 15 | 17 | 4.25 |
| 11 | Louisiana Tech | 4 | 4 | 10 | 14 | 3.50 |
| 12 | UTSA | 4 | 2 | 10 | 12 | 3.00 |
| 13 | Charlotte | 4 | 4 | 7 | 11 | 2.75 |
| 13 | Florida International | 4 | 2 | 9 | 11 | 2.75 |