2021 Conference USA Leaders Passes Defended - Games on the Road/Neutral Site Only through 01/10/2022
| Name | G | Int. | Passes Broken Up | Passes Defended | Passes Defended/G | |
|---|---|---|---|---|---|---|
| 1 | Middle Tennessee | 8 | 9 | 43 | 52 | 6.50 |
| 2 | Western Kentucky | 8 | 9 | 34 | 43 | 5.38 |
| 3 | UAB | 8 | 6 | 29 | 35 | 4.38 |
| 4 | UTSA | 7 | 3 | 27 | 30 | 4.29 |
| 5 | Marshall | 7 | 7 | 21 | 28 | 4.00 |
| 6 | Old Dominion | 7 | 4 | 22 | 26 | 3.71 |
| 7 | UTEP | 7 | 2 | 23 | 25 | 3.57 |
| 8 | Florida Atlantic | 6 | 6 | 17 | 23 | 3.83 |
| 9 | Rice | 6 | 4 | 18 | 22 | 3.67 |
| 10 | Charlotte | 6 | 7 | 14 | 21 | 3.50 |
| 10 | Louisiana Tech | 6 | 5 | 16 | 21 | 3.50 |
| 12 | Southern Mississippi | 6 | 6 | 11 | 17 | 2.83 |
| 13 | North Texas | 7 | 3 | 13 | 16 | 2.29 |
| 14 | Florida International | 6 | 2 | 12 | 14 | 2.33 |