2021 Big 12 Conference Leaders Total Defense - Games in November Only through 01/10/2022
| Name | G | Rush Yards | Pass Yards | Plays | Total Yards | Yards/Play | Yards/G | |
|---|---|---|---|---|---|---|---|---|
| 1 | Oklahoma State | 4 | 364 | 653 | 251 | 1017 | 4.05 | 254.3 |
| 2 | West Virginia | 4 | 554 | 721 | 239 | 1275 | 5.33 | 318.8 |
| 3 | Iowa State | 4 | 647 | 737 | 249 | 1384 | 5.56 | 346.0 |
| 4 | Kansas State | 4 | 548 | 839 | 281 | 1387 | 4.94 | 346.8 |
| 5 | Baylor | 4 | 405 | 1073 | 234 | 1478 | 6.32 | 369.5 |
| 6 | Oklahoma | 3 | 488 | 641 | 221 | 1129 | 5.11 | 376.3 |
| 7 | Texas | 4 | 779 | 869 | 282 | 1648 | 5.84 | 412.0 |
| 8 | Texas Tech | 3 | 457 | 849 | 238 | 1306 | 5.49 | 435.3 |
| 9 | TCU | 4 | 1029 | 966 | 257 | 1995 | 7.76 | 498.8 |
| 10 | Kansas | 4 | 993 | 1008 | 275 | 2001 | 7.28 | 500.3 |