2021 Big 12 Conference Leaders Total Defense - Games on the Road/Neutral Site Only through 01/10/2022
| Name | G | Rush Yards | Pass Yards | Plays | Total Yards | Yards/Play | Yards/G | |
|---|---|---|---|---|---|---|---|---|
| 1 | Oklahoma State | 7 | 412 | 1616 | 461 | 2028 | 4.40 | 289.7 |
| 2 | Baylor | 7 | 810 | 1468 | 503 | 2278 | 4.53 | 325.4 |
| 3 | Kansas State | 6 | 813 | 1182 | 360 | 1995 | 5.54 | 332.5 |
| 4 | Iowa State | 7 | 960 | 1428 | 427 | 2388 | 5.59 | 341.1 |
| 5 | West Virginia | 7 | 1038 | 1682 | 449 | 2720 | 6.06 | 388.6 |
| 6 | Texas Tech | 7 | 958 | 1948 | 483 | 2906 | 6.02 | 415.1 |
| 7 | Oklahoma | 6 | 1022 | 1591 | 401 | 2613 | 6.52 | 435.5 |
| 8 | Texas | 6 | 1405 | 1441 | 450 | 2846 | 6.32 | 474.3 |
| 9 | Kansas | 6 | 1566 | 1666 | 427 | 3232 | 7.57 | 538.7 |
| 10 | TCU | 5 | 1316 | 1378 | 331 | 2694 | 8.14 | 538.8 |