2021 Atlantic Coast Conference Leaders Opponent First Downs - All Games through 01/10/2022
| Name | G | Rush | Pass | Penalty | Total | Total/G | |
|---|---|---|---|---|---|---|---|
| 1 | Clemson | 13 | 74 | 128 | 22 | 224 | 17.2 |
| 2 | North Carolina State | 12 | 70 | 108 | 32 | 210 | 17.5 |
| 3 | Syracuse | 12 | 98 | 102 | 21 | 221 | 18.4 |
| 4 | Boston College | 12 | 106 | 94 | 23 | 223 | 18.6 |
| 5 | Pittsburgh | 14 | 80 | 162 | 36 | 278 | 19.9 |
| 6 | Virginia Tech | 13 | 122 | 123 | 20 | 265 | 20.4 |
| 7 | Florida State | 12 | 94 | 125 | 27 | 246 | 20.5 |
| 8 | Miami (Florida) | 12 | 98 | 126 | 23 | 247 | 20.6 |
| 9 | Louisville | 13 | 117 | 146 | 25 | 288 | 22.2 |
| 10 | Georgia Tech | 12 | 116 | 132 | 20 | 268 | 22.3 |
| 11 | Wake Forest | 14 | 148 | 137 | 28 | 313 | 22.4 |
| 12 | North Carolina | 13 | 134 | 132 | 34 | 300 | 23.1 |
| 13 | Virginia | 12 | 120 | 132 | 29 | 281 | 23.4 |
| 14 | Duke | 12 | 114 | 155 | 24 | 293 | 24.4 |