2021 Atlantic Coast Conference Leaders Opponent First Downs - Games Lost Only through 01/10/2022
| Name | G | Rush | Pass | Penalty | Total | Total/G | |
|---|---|---|---|---|---|---|---|
| 1 | Syracuse | 7 | 54 | 68 | 12 | 134 | 19.1 |
| 2 | Boston College | 6 | 62 | 47 | 10 | 119 | 19.8 |
| 3 | North Carolina State | 3 | 9 | 42 | 9 | 60 | 20.0 |
| 4 | Florida State | 7 | 48 | 84 | 14 | 146 | 20.9 |
| 5 | Virginia Tech | 7 | 74 | 67 | 9 | 150 | 21.4 |
| 6 | North Carolina | 7 | 82 | 62 | 15 | 159 | 22.7 |
| 7 | Georgia Tech | 9 | 94 | 101 | 15 | 210 | 23.3 |
| 8 | Clemson | 3 | 25 | 36 | 11 | 72 | 24.0 |
| 9 | Miami (Florida) | 5 | 53 | 52 | 16 | 121 | 24.2 |
| 10 | Louisville | 7 | 64 | 95 | 11 | 170 | 24.3 |
| 11 | Duke | 9 | 87 | 128 | 16 | 231 | 25.7 |
| 12 | Wake Forest | 3 | 39 | 31 | 8 | 78 | 26.0 |
| 13 | Pittsburgh | 3 | 18 | 51 | 10 | 79 | 26.3 |
| 14 | Virginia | 6 | 78 | 71 | 17 | 166 | 27.7 |