2021 Atlantic Coast Conference Leaders Opponent First Downs - Games in November Only through 01/10/2022
| Name | G | Rush | Pass | Penalty | Total | Total/G | |
|---|---|---|---|---|---|---|---|
| 1 | Clemson | 4 | 18 | 37 | 5 | 60 | 15.0 |
| 2 | Miami (Florida) | 4 | 31 | 32 | 9 | 72 | 18.0 |
| 3 | Syracuse | 3 | 21 | 30 | 5 | 56 | 18.7 |
| 4 | Florida State | 4 | 30 | 41 | 8 | 79 | 19.8 |
| 5 | Pittsburgh | 4 | 26 | 49 | 8 | 83 | 20.8 |
| 5 | North Carolina State | 4 | 29 | 39 | 15 | 83 | 20.8 |
| 7 | Boston College | 4 | 42 | 32 | 10 | 84 | 21.0 |
| 8 | Virginia Tech | 4 | 35 | 42 | 11 | 88 | 22.0 |
| 9 | Wake Forest | 4 | 45 | 38 | 7 | 90 | 22.5 |
| 10 | Louisville | 4 | 46 | 38 | 8 | 92 | 23.0 |
| 11 | Virginia | 3 | 29 | 35 | 6 | 70 | 23.3 |
| 12 | Georgia Tech | 4 | 39 | 46 | 9 | 94 | 23.5 |
| 13 | North Carolina | 4 | 40 | 47 | 12 | 99 | 24.8 |
| 14 | Duke | 4 | 47 | 61 | 7 | 115 | 28.8 |