2021 Atlantic Coast Conference Leaders Opponent First Downs - Games at Home Only through 01/10/2022
| Name | G | Rush | Pass | Penalty | Total | Total/G | |
|---|---|---|---|---|---|---|---|
| 1 | Clemson | 6 | 24 | 60 | 7 | 91 | 15.2 |
| 2 | North Carolina State | 7 | 50 | 48 | 17 | 115 | 16.4 |
| 3 | Syracuse | 7 | 53 | 58 | 11 | 122 | 17.4 |
| 4 | Miami (Florida) | 7 | 56 | 62 | 9 | 127 | 18.1 |
| 5 | Boston College | 6 | 47 | 53 | 9 | 109 | 18.2 |
| 6 | Florida State | 7 | 40 | 77 | 11 | 128 | 18.3 |
| 7 | Wake Forest | 6 | 45 | 60 | 9 | 114 | 19.0 |
| 8 | Pittsburgh | 7 | 36 | 82 | 17 | 135 | 19.3 |
| 9 | Virginia Tech | 7 | 70 | 61 | 10 | 141 | 20.1 |
| 10 | Louisville | 7 | 60 | 67 | 15 | 142 | 20.3 |
| 11 | Virginia | 7 | 59 | 71 | 14 | 144 | 20.6 |
| 12 | Georgia Tech | 6 | 55 | 59 | 11 | 125 | 20.8 |
| 13 | North Carolina | 7 | 66 | 76 | 21 | 163 | 23.3 |
| 14 | Duke | 7 | 69 | 86 | 16 | 171 | 24.4 |