2021 Atlantic Coast Conference Leaders Scoring Defense - Games vs. Conference Teams Only through 01/10/2022
| Name | G | TD | FG | 1XP | 2XP | Safety | Points | Points/G | |
|---|---|---|---|---|---|---|---|---|---|
| 1 | Clemson | 8 | 19 | 9 | 15 | 1 | 1 | 160 | 20.0 |
| 2 | North Carolina State | 8 | 22 | 8 | 22 | 0 | 0 | 178 | 22.3 |
| 3 | Pittsburgh | 9 | 27 | 6 | 26 | 0 | 1 | 208 | 23.1 |
| 4 | Louisville | 8 | 22 | 13 | 20 | 0 | 0 | 191 | 23.9 |
| 5 | Virginia Tech | 8 | 25 | 6 | 24 | 0 | 0 | 192 | 24.0 |
| 6 | Boston College | 8 | 24 | 10 | 23 | 0 | 2 | 201 | 25.1 |
| 7 | Florida State | 8 | 30 | 7 | 25 | 2 | 0 | 230 | 28.8 |
| 8 | Miami (Florida) | 8 | 27 | 14 | 24 | 3 | 1 | 236 | 29.5 |
| 9 | Syracuse | 8 | 29 | 14 | 25 | 2 | 0 | 245 | 30.6 |
| 10 | Wake Forest | 10 | 39 | 13 | 37 | 1 | 0 | 312 | 31.2 |
| 11 | Georgia Tech | 8 | 32 | 13 | 30 | 1 | 0 | 263 | 32.9 |
| 12 | North Carolina | 9 | 39 | 10 | 34 | 3 | 0 | 304 | 33.8 |
| 13 | Virginia | 8 | 33 | 14 | 30 | 1 | 1 | 274 | 34.3 |
| 14 | Duke | 8 | 47 | 15 | 46 | 0 | 0 | 373 | 46.6 |