2021 Atlantic Coast Conference Leaders Scoring Defense - Games in August/September Only through 01/10/2022
| Name | G | TD | FG | 1XP | 2XP | Safety | Points | Points/G | |
|---|---|---|---|---|---|---|---|---|---|
| 1 | Clemson | 4 | 5 | 4 | 4 | 0 | 1 | 48 | 12.0 |
| 2 | North Carolina State | 4 | 7 | 1 | 7 | 0 | 0 | 52 | 13.0 |
| 3 | Wake Forest | 4 | 7 | 3 | 6 | 0 | 0 | 57 | 14.3 |
| 4 | Virginia Tech | 4 | 7 | 4 | 7 | 0 | 0 | 61 | 15.3 |
| 5 | Boston College | 4 | 8 | 3 | 8 | 0 | 0 | 65 | 16.3 |
| 6 | Syracuse | 4 | 8 | 5 | 8 | 0 | 0 | 71 | 17.8 |
| 7 | Georgia Tech | 4 | 10 | 1 | 8 | 2 | 0 | 75 | 18.8 |
| 8 | Pittsburgh | 4 | 12 | 3 | 11 | 0 | 0 | 92 | 23.0 |
| 9 | Duke | 4 | 13 | 5 | 11 | 0 | 0 | 104 | 26.0 |
| 9 | Louisville | 4 | 13 | 5 | 11 | 0 | 0 | 104 | 26.0 |
| 11 | Miami (Florida) | 5 | 16 | 7 | 14 | 1 | 1 | 135 | 27.0 |
| 12 | Virginia | 5 | 18 | 4 | 18 | 0 | 0 | 138 | 27.6 |
| 13 | North Carolina | 4 | 14 | 6 | 12 | 2 | 0 | 118 | 29.5 |
| 14 | Florida State | 4 | 16 | 5 | 14 | 1 | 0 | 127 | 31.8 |