2021 Atlantic Coast Conference Leaders Opponent First Downs - Games in October Only through 01/10/2022
| Name | G | Rush | Pass | Penalty | Total | Total/G | |
|---|---|---|---|---|---|---|---|
| 1 | Boston College | 4 | 41 | 26 | 5 | 72 | 18.0 |
| 1 | Clemson | 4 | 26 | 44 | 5 | 75 | 18.8 |
| 1 | Virginia Tech | 4 | 41 | 38 | 5 | 84 | 21.0 |
| 4 | Virginia | 4 | 43 | 53 | 6 | 102 | 25.5 |
| 4 | Georgia Tech | 4 | 45 | 58 | 6 | 109 | 27.3 |
| 6 | Syracuse | 5 | 43 | 49 | 7 | 99 | 19.8 |
| 6 | Louisville | 4 | 21 | 60 | 7 | 88 | 22.0 |
| 6 | Miami (Florida) | 3 | 24 | 40 | 7 | 71 | 23.7 |
| 9 | Florida State | 4 | 39 | 33 | 9 | 81 | 20.3 |
| 9 | Duke | 4 | 35 | 52 | 9 | 96 | 24.0 |
| 9 | Wake Forest | 4 | 63 | 29 | 9 | 101 | 25.3 |
| 12 | North Carolina State | 4 | 27 | 39 | 12 | 78 | 19.5 |
| 12 | Pittsburgh | 4 | 23 | 45 | 12 | 80 | 20.0 |
| 14 | North Carolina | 4 | 44 | 35 | 16 | 95 | 23.8 |