2021 Atlantic Coast Conference Leaders Opponent First Downs - Games on the Road/Neutral Site Only through 01/10/2022
| Name | G | Rush | Pass | Penalty | Total | Total/G | |
|---|---|---|---|---|---|---|---|
| 1 | Duke | 5 | 45 | 69 | 8 | 122 | 24.4 |
| 2 | Georgia Tech | 6 | 61 | 73 | 9 | 143 | 23.8 |
| 3 | Syracuse | 5 | 45 | 44 | 10 | 99 | 19.8 |
| 3 | Virginia Tech | 6 | 52 | 62 | 10 | 124 | 20.7 |
| 3 | Louisville | 6 | 57 | 79 | 10 | 146 | 24.3 |
| 6 | North Carolina | 6 | 68 | 56 | 13 | 137 | 22.8 |
| 7 | Boston College | 6 | 59 | 41 | 14 | 114 | 19.0 |
| 7 | Miami (Florida) | 5 | 42 | 64 | 14 | 120 | 24.0 |
| 9 | North Carolina State | 5 | 20 | 60 | 15 | 95 | 19.0 |
| 9 | Clemson | 7 | 50 | 68 | 15 | 133 | 19.0 |
| 9 | Virginia | 5 | 61 | 61 | 15 | 137 | 27.4 |
| 12 | Florida State | 5 | 54 | 48 | 16 | 118 | 23.6 |
| 13 | Pittsburgh | 7 | 44 | 80 | 19 | 143 | 20.4 |
| 13 | Wake Forest | 8 | 103 | 77 | 19 | 199 | 24.9 |