2021 Atlantic Coast Conference Leaders Tackles For Loss - Games vs. Non-Conference Teams Only through 01/10/2022
| Name | G | TFL | TFL Yards | TFL/G | |
|---|---|---|---|---|---|
| 1 | Syracuse | 4 | 39.0 | 143 | 9.75 |
| 2 | Pittsburgh | 5 | 37.0 | 199 | 7.40 |
| 3 | Florida State | 4 | 33.0 | 96 | 8.25 |
| 4 | Clemson | 5 | 32.0 | 113 | 6.40 |
| 5 | Miami (Florida) | 4 | 29.0 | 127 | 7.25 |
| 6 | Wake Forest | 4 | 28.0 | 85 | 7.00 |
| 7 | Louisville | 5 | 25.0 | 92 | 5.00 |
| 7 | North Carolina | 4 | 25.0 | 68 | 6.25 |
| 9 | Duke | 4 | 22.0 | 81 | 5.50 |
| 9 | Virginia Tech | 5 | 22.0 | 81 | 4.40 |
| 11 | North Carolina State | 4 | 19.0 | 61 | 4.75 |
| 12 | Georgia Tech | 4 | 18.0 | 92 | 4.50 |
| 12 | Boston College | 4 | 18.0 | 68 | 4.50 |
| 12 | Virginia | 4 | 18.0 | 56 | 4.50 |