2021 Atlantic Coast Conference Leaders Tackles For Loss - Games in October Only through 01/10/2022
| Name | G | TFL | TFL Yards | TFL/G | |
|---|---|---|---|---|---|
| 1 | Syracuse | 5 | 29.0 | 140 | 5.80 |
| 2 | Louisville | 4 | 28.0 | 101 | 7.00 |
| 3 | Clemson | 4 | 27.0 | 114 | 6.75 |
| 3 | Pittsburgh | 4 | 27.0 | 114 | 6.75 |
| 3 | Florida State | 4 | 27.0 | 78 | 6.75 |
| 6 | North Carolina State | 4 | 26.0 | 82 | 6.50 |
| 7 | North Carolina | 4 | 22.0 | 73 | 5.50 |
| 8 | Duke | 4 | 21.0 | 94 | 5.25 |
| 9 | Miami (Florida) | 3 | 20.0 | 100 | 6.67 |
| 9 | Wake Forest | 4 | 20.0 | 66 | 5.00 |
| 11 | Georgia Tech | 4 | 17.0 | 63 | 4.25 |
| 12 | Virginia Tech | 4 | 16.0 | 52 | 4.00 |
| 13 | Boston College | 4 | 15.0 | 87 | 3.75 |
| 13 | Virginia | 4 | 15.0 | 43 | 3.75 |