2021 Atlantic Coast Conference Leaders Tackles For Loss - Games vs. FBS non-Power 5 Conference Teams Only through 01/10/2022
| Name | G | TFL | TFL Yards | TFL/G | |
|---|---|---|---|---|---|
| 1 | Florida State | 2 | 18.0 | 44 | 9.00 |
| 2 | Pittsburgh | 2 | 13.0 | 73 | 6.50 |
| 3 | North Carolina State | 2 | 12.0 | 48 | 6.00 |
| 3 | Syracuse | 2 | 12.0 | 42 | 6.00 |
| 3 | North Carolina | 2 | 12.0 | 25 | 6.00 |
| 6 | Virginia Tech | 2 | 11.0 | 46 | 5.50 |
| 6 | Boston College | 2 | 11.0 | 37 | 5.50 |
| 8 | Clemson | 1 | 10.0 | 53 | 10.00 |
| 8 | Wake Forest | 2 | 10.0 | 27 | 5.00 |
| 10 | Louisville | 2 | 9.0 | 46 | 4.50 |
| 10 | Duke | 1 | 9.0 | 29 | 9.00 |
| 12 | Miami (Florida) | 1 | 7.0 | 12 | 7.00 |
| 13 | Georgia Tech | 2 | 6.0 | 42 | 3.00 |
| 14 | Virginia | 2 | 5.0 | 10 | 2.50 |