2021 Atlantic Coast Conference Leaders Tackles For Loss - Games vs. FBS Teams With Non-Winning Record Only through 01/10/2022
| Name | G | TFL | TFL Yards | TFL/G | |
|---|---|---|---|---|---|
| 1 | Wake Forest | 9 | 68.0 | 248 | 7.56 |
| 2 | Pittsburgh | 7 | 60.0 | 282 | 8.57 |
| 3 | Miami (Florida) | 6 | 53.0 | 203 | 8.83 |
| 4 | North Carolina State | 7 | 52.0 | 198 | 7.43 |
| 5 | Clemson | 6 | 51.0 | 237 | 8.50 |
| 6 | Syracuse | 6 | 43.0 | 171 | 7.17 |
| 7 | Duke | 8 | 42.0 | 174 | 5.25 |
| 8 | Louisville | 5 | 41.0 | 175 | 8.20 |
| 9 | Virginia Tech | 7 | 39.0 | 158 | 5.57 |
| 9 | Florida State | 6 | 39.0 | 111 | 6.50 |
| 11 | Boston College | 8 | 38.0 | 197 | 4.75 |
| 12 | Georgia Tech | 5 | 31.0 | 127 | 6.20 |
| 13 | Virginia | 6 | 26.0 | 86 | 4.33 |
| 14 | North Carolina | 5 | 25.0 | 103 | 5.00 |