2021 Atlantic Coast Conference Leaders Passes Defended - Games Won Only through 01/10/2022
| Name | G | Int. | Passes Broken Up | Passes Defended | Passes Defended/G | |
|---|---|---|---|---|---|---|
| 1 | Clemson | 10 | 11 | 45 | 56 | 5.60 |
| 2 | Pittsburgh | 11 | 14 | 39 | 53 | 4.82 |
| 3 | North Carolina State | 9 | 12 | 39 | 51 | 5.67 |
| 4 | Wake Forest | 11 | 14 | 32 | 46 | 4.18 |
| 5 | Florida State | 5 | 7 | 22 | 29 | 5.80 |
| 5 | Virginia | 6 | 4 | 25 | 29 | 4.83 |
| 7 | North Carolina | 6 | 9 | 19 | 28 | 4.67 |
| 8 | Boston College | 6 | 7 | 19 | 26 | 4.33 |
| 8 | Louisville | 6 | 7 | 19 | 26 | 4.33 |
| 8 | Virginia Tech | 6 | 6 | 20 | 26 | 4.33 |
| 11 | Miami (Florida) | 7 | 6 | 19 | 25 | 3.57 |
| 12 | Duke | 3 | 5 | 12 | 17 | 5.67 |
| 13 | Syracuse | 5 | 1 | 14 | 15 | 3.00 |
| 14 | Georgia Tech | 3 | 3 | 6 | 9 | 3.00 |