2021 Atlantic Coast Conference Leaders Passes Defended - Games at Home Only through 01/10/2022
| Name | G | Int. | Passes Broken Up | Passes Defended | Passes Defended/G | |
|---|---|---|---|---|---|---|
| 1 | North Carolina State | 7 | 10 | 27 | 37 | 5.29 |
| 1 | Florida State | 7 | 7 | 30 | 37 | 5.29 |
| 3 | Clemson | 6 | 7 | 26 | 33 | 5.50 |
| 3 | Pittsburgh | 7 | 6 | 27 | 33 | 4.71 |
| 5 | Duke | 7 | 7 | 25 | 32 | 4.57 |
| 5 | Virginia Tech | 7 | 6 | 26 | 32 | 4.57 |
| 7 | Virginia | 7 | 5 | 26 | 31 | 4.43 |
| 8 | North Carolina | 7 | 9 | 20 | 29 | 4.14 |
| 9 | Wake Forest | 6 | 8 | 20 | 28 | 4.67 |
| 9 | Louisville | 7 | 7 | 21 | 28 | 4.00 |
| 11 | Boston College | 6 | 5 | 22 | 27 | 4.50 |
| 12 | Miami (Florida) | 7 | 4 | 22 | 26 | 3.71 |
| 13 | Syracuse | 7 | 2 | 17 | 19 | 2.71 |
| 14 | Georgia Tech | 6 | 2 | 9 | 11 | 1.83 |