2021 Atlantic Coast Conference Leaders Passes Defended - Games vs. Ranked Teams Only (AP Poll) through 01/10/2022
| Name | G | Int. | Passes Broken Up | Passes Defended | Passes Defended/G | |
|---|---|---|---|---|---|---|
| 1 | North Carolina | 4 | 3 | 20 | 23 | 5.75 |
| 2 | Pittsburgh | 3 | 7 | 15 | 22 | 7.33 |
| 2 | Virginia | 4 | 3 | 19 | 22 | 5.50 |
| 4 | Clemson | 4 | 2 | 19 | 21 | 5.25 |
| 5 | Louisville | 5 | 1 | 18 | 19 | 3.80 |
| 6 | North Carolina State | 2 | 4 | 9 | 13 | 6.50 |
| 6 | Syracuse | 4 | 2 | 11 | 13 | 3.25 |
| 8 | Boston College | 3 | 1 | 11 | 12 | 4.00 |
| 8 | Florida State | 4 | 4 | 8 | 12 | 3.00 |
| 10 | Duke | 2 | 0 | 11 | 11 | 5.50 |
| 10 | Miami (Florida) | 4 | 2 | 9 | 11 | 2.75 |
| 12 | Wake Forest | 3 | 3 | 7 | 10 | 3.33 |
| 13 | Virginia Tech | 2 | 2 | 7 | 9 | 4.50 |
| 14 | Georgia Tech | 4 | 0 | 3 | 3 | 0.75 |