2021 Atlantic Coast Conference Leaders Passes Defended - Games vs. FBS Teams With Non-Winning Record Only through 01/10/2022
| Name | G | Int. | Passes Broken Up | Passes Defended | Passes Defended/G | |
|---|---|---|---|---|---|---|
| 1 | North Carolina State | 7 | 10 | 31 | 41 | 5.86 |
| 2 | Wake Forest | 9 | 10 | 30 | 40 | 4.44 |
| 3 | Duke | 8 | 8 | 28 | 36 | 4.50 |
| 4 | Virginia Tech | 7 | 7 | 25 | 32 | 4.57 |
| 5 | Louisville | 5 | 6 | 24 | 30 | 6.00 |
| 6 | Clemson | 6 | 6 | 22 | 28 | 4.67 |
| 6 | Virginia | 6 | 5 | 23 | 28 | 4.67 |
| 6 | Boston College | 8 | 7 | 21 | 28 | 3.50 |
| 9 | Florida State | 6 | 8 | 18 | 26 | 4.33 |
| 9 | Pittsburgh | 7 | 6 | 20 | 26 | 3.71 |
| 11 | Miami (Florida) | 6 | 4 | 13 | 17 | 2.83 |
| 12 | Georgia Tech | 5 | 1 | 14 | 15 | 3.00 |
| 12 | Syracuse | 6 | 2 | 13 | 15 | 2.50 |
| 14 | North Carolina | 5 | 3 | 8 | 11 | 2.20 |