2021 Atlantic Coast Conference Leaders Passes Defended - Games vs. FBS non-Power 5 Conference Teams Only through 01/10/2022
| Name | G | Int. | Passes Broken Up | Passes Defended | Passes Defended/G | |
|---|---|---|---|---|---|---|
| 1 | North Carolina State | 2 | 5 | 7 | 12 | 6.00 |
| 2 | Wake Forest | 2 | 3 | 8 | 11 | 5.50 |
| 3 | Virginia | 2 | 1 | 9 | 10 | 5.00 |
| 4 | Virginia Tech | 2 | 3 | 6 | 9 | 4.50 |
| 5 | Florida State | 2 | 3 | 5 | 8 | 4.00 |
| 5 | Boston College | 2 | 2 | 6 | 8 | 4.00 |
| 5 | Pittsburgh | 2 | 0 | 8 | 8 | 4.00 |
| 8 | Syracuse | 2 | 1 | 5 | 6 | 3.00 |
| 9 | Clemson | 1 | 2 | 3 | 5 | 5.00 |
| 9 | Miami (Florida) | 1 | 1 | 4 | 5 | 5.00 |
| 11 | Duke | 1 | 0 | 4 | 4 | 4.00 |
| 11 | North Carolina | 2 | 1 | 3 | 4 | 2.00 |
| 13 | Louisville | 2 | 1 | 2 | 3 | 1.50 |
| 13 | Georgia Tech | 2 | 0 | 3 | 3 | 1.50 |