2021 Atlantic Coast Conference Leaders Sacks - Games vs. Unranked Teams Only (AP Poll) through 01/10/2022
| Name | G | Sacks | Sack Yards | Sacks/G | |
|---|---|---|---|---|---|
| 1 | Pittsburgh | 11 | 45.0 | 345 | 4.09 |
| 2 | Clemson | 9 | 28.0 | 193 | 3.11 |
| 3 | Syracuse | 8 | 29.0 | 177 | 3.63 |
| 3 | Miami (Florida) | 8 | 24.0 | 177 | 3.00 |
| 5 | Wake Forest | 11 | 33.0 | 170 | 3.00 |
| 6 | Louisville | 8 | 24.0 | 168 | 3.00 |
| 7 | Virginia Tech | 11 | 22.0 | 149 | 2.00 |
| 8 | North Carolina State | 10 | 28.0 | 148 | 2.80 |
| 9 | Boston College | 9 | 16.0 | 137 | 1.78 |
| 10 | North Carolina | 9 | 16.0 | 112 | 1.78 |
| 11 | Duke | 10 | 15.0 | 108 | 1.50 |
| 12 | Florida State | 8 | 20.0 | 95 | 2.50 |
| 12 | Georgia Tech | 8 | 15.0 | 95 | 1.88 |
| 14 | Virginia | 8 | 15.0 | 83 | 1.88 |