2021 Atlantic Coast Conference Leaders Sacks - Games vs. FBS Power 5 Conference Teams Only through 01/10/2022
| Name | G | Sacks | Sack Yards | Sacks/G | |
|---|---|---|---|---|---|
| 1 | Pittsburgh | 11 | 43.0 | 308 | 3.91 |
| 2 | Clemson | 11 | 35.0 | 228 | 3.18 |
| 3 | Miami (Florida) | 10 | 29.0 | 222 | 2.90 |
| 4 | Wake Forest | 11 | 32.0 | 200 | 2.91 |
| 5 | North Carolina | 10 | 27.0 | 187 | 2.70 |
| 6 | Louisville | 10 | 28.0 | 182 | 2.80 |
| 7 | Syracuse | 9 | 23.0 | 165 | 2.56 |
| 8 | North Carolina State | 9 | 29.0 | 153 | 3.22 |
| 9 | Boston College | 9 | 15.0 | 123 | 1.67 |
| 10 | Duke | 10 | 19.0 | 118 | 1.90 |
| 11 | Virginia Tech | 10 | 18.0 | 117 | 1.80 |
| 12 | Florida State | 9 | 20.0 | 111 | 2.22 |
| 13 | Virginia | 9 | 17.0 | 99 | 1.89 |
| 14 | Georgia Tech | 9 | 15.0 | 91 | 1.67 |