2021 Atlantic Coast Conference Leaders Sacks - Games vs. FBS (I-A) Teams Only through 01/10/2022
| Name | G | Sacks | Sack Yards | Sacks/G | |
|---|---|---|---|---|---|
| 1 | Pittsburgh | 13 | 51.0 | 370 | 3.92 |
| 2 | Clemson | 12 | 41.0 | 272 | 3.42 |
| 3 | Miami (Florida) | 11 | 30.0 | 224 | 2.73 |
| 4 | Louisville | 12 | 32.0 | 213 | 2.67 |
| 5 | Wake Forest | 13 | 35.0 | 209 | 2.69 |
| 6 | Syracuse | 11 | 29.0 | 196 | 2.64 |
| 7 | North Carolina | 12 | 29.0 | 194 | 2.42 |
| 8 | North Carolina State | 11 | 32.0 | 170 | 2.91 |
| 9 | Virginia Tech | 12 | 23.0 | 149 | 1.92 |
| 10 | Boston College | 11 | 19.0 | 142 | 1.73 |
| 11 | Florida State | 11 | 28.0 | 137 | 2.55 |
| 12 | Duke | 11 | 20.0 | 123 | 1.82 |
| 13 | Georgia Tech | 11 | 18.0 | 118 | 1.64 |
| 14 | Virginia | 11 | 17.0 | 99 | 1.55 |