2021 Atlantic Coast Conference Leaders Sacks - Games in August/September Only through 01/10/2022
| Name | G | Sacks | Sack Yards | Sacks/G | |
|---|---|---|---|---|---|
| 1 | Pittsburgh | 4 | 16.0 | 132 | 4.00 |
| 2 | Syracuse | 4 | 18.0 | 99 | 4.50 |
| 3 | Miami (Florida) | 5 | 11.0 | 87 | 2.20 |
| 4 | Wake Forest | 4 | 15.0 | 78 | 3.75 |
| 5 | Virginia Tech | 4 | 13.0 | 76 | 3.25 |
| 6 | Louisville | 4 | 11.0 | 75 | 2.75 |
| 7 | Georgia Tech | 4 | 10.0 | 66 | 2.50 |
| 7 | Clemson | 4 | 9.0 | 66 | 2.25 |
| 9 | Florida State | 4 | 13.0 | 58 | 3.25 |
| 10 | Virginia | 5 | 9.0 | 48 | 1.80 |
| 11 | Duke | 4 | 5.0 | 45 | 1.25 |
| 12 | North Carolina | 4 | 6.0 | 43 | 1.50 |
| 13 | Boston College | 4 | 6.0 | 31 | 1.50 |
| 14 | North Carolina State | 4 | 4.0 | 13 | 1.00 |