2021 Atlantic Coast Conference Leaders Interceptions - Games in August/September Only through 01/10/2022
| Name | G | Int. | Yards | TD | Int./G | |
|---|---|---|---|---|---|---|
| 1 | Wake Forest | 4 | 7 | 91 | 0 | 1.75 |
| 2 | Boston College | 4 | 6 | 15 | 1 | 1.50 |
| 3 | Duke | 4 | 5 | 55 | 0 | 1.25 |
| 3 | Virginia Tech | 4 | 5 | 41 | 0 | 1.25 |
| 3 | North Carolina State | 4 | 5 | 29 | 0 | 1.25 |
| 6 | Louisville | 4 | 4 | 68 | 1 | 1.00 |
| 7 | Clemson | 4 | 3 | 40 | 0 | 0.75 |
| 7 | North Carolina | 4 | 3 | 17 | 0 | 0.75 |
| 7 | Miami (Florida) | 5 | 3 | 9 | 0 | 0.60 |
| 10 | Pittsburgh | 4 | 2 | 60 | 1 | 0.50 |
| 10 | Florida State | 4 | 2 | 5 | 0 | 0.50 |
| 10 | Georgia Tech | 4 | 2 | 0 | 0 | 0.50 |
| 10 | Virginia | 5 | 2 | 66 | 0 | 0.40 |
| 14 | Syracuse | 4 | 1 | 23 | 0 | 0.25 |