2021 Atlantic Coast Conference Leaders Interceptions - Games vs. FBS Power 5 Conference Teams Only through 01/10/2022
| Name | G | Int. | Yards | TD | Int./G | |
|---|---|---|---|---|---|---|
| 1 | Pittsburgh | 11 | 15 | 230 | 3 | 1.36 |
| 2 | Florida State | 9 | 11 | 75 | 0 | 1.22 |
| 2 | Wake Forest | 11 | 11 | 17 | 0 | 1.00 |
| 4 | North Carolina State | 9 | 9 | 6 | 1 | 1.00 |
| 4 | North Carolina | 10 | 9 | 45 | 0 | 0.90 |
| 4 | Clemson | 11 | 9 | 30 | 1 | 0.82 |
| 7 | Duke | 10 | 8 | 101 | 0 | 0.80 |
| 8 | Virginia | 9 | 7 | 126 | 0 | 0.78 |
| 8 | Louisville | 10 | 7 | 93 | 0 | 0.70 |
| 8 | Virginia Tech | 10 | 7 | 27 | 0 | 0.70 |
| 11 | Boston College | 9 | 6 | 8 | 0 | 0.67 |
| 11 | Miami (Florida) | 10 | 6 | 113 | 1 | 0.60 |
| 13 | Syracuse | 9 | 3 | 9 | 0 | 0.33 |
| 14 | Georgia Tech | 9 | 1 | 6 | 0 | 0.11 |