2021 Atlantic Coast Conference Leaders Interceptions - Games vs. Unranked Teams Only (AP Poll) through 01/10/2022
| Name | G | Int. | Yards | TD | Int./G | |
|---|---|---|---|---|---|---|
| 1 | Wake Forest | 11 | 12 | 177 | 1 | 1.09 |
| 2 | North Carolina State | 10 | 11 | 30 | 1 | 1.10 |
| 3 | Florida State | 8 | 10 | 100 | 1 | 1.25 |
| 3 | Clemson | 9 | 10 | 66 | 1 | 1.11 |
| 5 | Louisville | 8 | 9 | 132 | 1 | 1.13 |
| 5 | Boston College | 9 | 9 | 27 | 1 | 1.00 |
| 5 | Pittsburgh | 11 | 9 | 108 | 2 | 0.82 |
| 8 | North Carolina | 9 | 8 | 50 | 0 | 0.89 |
| 8 | Duke | 10 | 8 | 101 | 0 | 0.80 |
| 8 | Virginia Tech | 11 | 8 | 57 | 0 | 0.73 |
| 11 | Miami (Florida) | 8 | 6 | 74 | 1 | 0.75 |
| 12 | Virginia | 8 | 5 | 93 | 0 | 0.63 |
| 13 | Georgia Tech | 8 | 3 | 6 | 0 | 0.38 |
| 14 | Syracuse | 8 | 2 | 23 | 0 | 0.25 |