2021 American Athletic Conference Leaders Passing Defense - Games vs. Non-Conference Teams Only through 01/10/2022
| Name | G | Att | Comp | Pct. | Yards | Yards/Att | TD | Int | Rating | Att/G | Yards/G | |
|---|---|---|---|---|---|---|---|---|---|---|---|---|
| 1 | Temple | 4 | 87 | 46 | 52.9 | 431 | 5.0 | 4 | 3 | 102.75 | 21.8 | 107.8 |
| 2 | Navy | 4 | 89 | 55 | 61.8 | 800 | 9.0 | 2 | 2 | 140.24 | 22.3 | 200.0 |
| 3 | Houston | 5 | 127 | 71 | 55.9 | 749 | 5.9 | 4 | 3 | 111.13 | 25.4 | 149.8 |
| 4 | South Florida | 4 | 125 | 79 | 63.2 | 1088 | 8.7 | 9 | 3 | 155.27 | 31.3 | 272.0 |
| 5 | Cincinnati | 5 | 171 | 83 | 48.5 | 920 | 5.4 | 6 | 9 | 94.78 | 34.2 | 184.0 |
| 6 | SMU | 4 | 158 | 89 | 56.3 | 1224 | 7.7 | 9 | 6 | 132.61 | 39.5 | 306.0 |
| 7 | Tulane | 4 | 129 | 90 | 69.8 | 1073 | 8.3 | 10 | 5 | 157.47 | 32.3 | 268.3 |
| 8 | East Carolina | 4 | 152 | 95 | 62.5 | 1307 | 8.6 | 6 | 5 | 141.18 | 38.0 | 326.8 |
| 9 | Tulsa | 5 | 152 | 100 | 65.8 | 1166 | 7.7 | 6 | 4 | 138.00 | 30.4 | 233.2 |
| 10 | UCF | 5 | 208 | 110 | 52.9 | 1173 | 5.6 | 6 | 6 | 104.01 | 41.6 | 234.6 |
| 11 | Memphis | 4 | 197 | 130 | 66.0 | 1394 | 7.1 | 10 | 1 | 141.16 | 49.3 | 348.5 |