2021 American Athletic Conference Leaders Opponent First Downs - Games vs. Non-Conference Teams Only through 01/10/2022
| Name | G | Rush | Pass | Penalty | Total | Total/G | |
|---|---|---|---|---|---|---|---|
| 1 | Houston | 5 | 27 | 29 | 8 | 64 | 12.8 |
| 2 | Navy | 4 | 33 | 32 | 4 | 69 | 17.3 |
| 2 | Temple | 4 | 38 | 25 | 6 | 69 | 17.3 |
| 4 | UCF | 5 | 28 | 60 | 7 | 95 | 19.0 |
| 5 | Tulsa | 5 | 32 | 56 | 10 | 98 | 19.6 |
| 5 | Cincinnati | 5 | 42 | 50 | 6 | 98 | 19.6 |
| 7 | SMU | 4 | 24 | 51 | 7 | 82 | 20.5 |
| 8 | South Florida | 4 | 38 | 50 | 6 | 94 | 23.5 |
| 9 | East Carolina | 4 | 39 | 50 | 10 | 99 | 24.8 |
| 10 | Memphis | 4 | 30 | 64 | 9 | 103 | 25.8 |
| 11 | Tulane | 4 | 42 | 49 | 13 | 104 | 26.0 |