2021 American Athletic Conference Leaders Opponent First Downs - Games on the Road/Neutral Site Only through 01/10/2022
| Name | G | Rush | Pass | Penalty | Total | Total/G | |
|---|---|---|---|---|---|---|---|
| 1 | Navy | 6 | 38 | 45 | 8 | 91 | 15.2 |
| 2 | Houston | 9 | 50 | 74 | 15 | 139 | 15.4 |
| 3 | Tulsa | 7 | 52 | 61 | 6 | 119 | 17.0 |
| 4 | East Carolina | 6 | 54 | 52 | 8 | 114 | 19.0 |
| 5 | Cincinnati | 7 | 65 | 68 | 12 | 145 | 20.7 |
| 6 | SMU | 6 | 42 | 78 | 8 | 128 | 21.3 |
| 7 | South Florida | 6 | 63 | 68 | 8 | 139 | 23.2 |
| 8 | UCF | 6 | 71 | 63 | 9 | 143 | 23.8 |
| 9 | Memphis | 5 | 51 | 62 | 7 | 120 | 24.0 |
| 10 | Temple | 6 | 80 | 62 | 9 | 151 | 25.2 |
| 11 | Tulane | 6 | 58 | 88 | 12 | 158 | 26.3 |