2021 American Athletic Conference Leaders Opponent First Downs - Games Won Only through 01/10/2022
| Name | G | Rush | Pass | Penalty | Total | Total/G | |
|---|---|---|---|---|---|---|---|
| 1 | Navy | 4 | 21 | 24 | 7 | 52 | 13.0 |
| 2 | South Florida | 2 | 7 | 20 | 1 | 28 | 14.0 |
| 3 | Houston | 12 | 69 | 95 | 25 | 189 | 15.8 |
| 4 | Tulane | 2 | 16 | 13 | 3 | 32 | 16.0 |
| 5 | SMU | 8 | 53 | 81 | 12 | 146 | 18.3 |
| 5 | UCF | 9 | 55 | 92 | 18 | 165 | 18.3 |
| 7 | Tulsa | 7 | 41 | 75 | 13 | 129 | 18.4 |
| 8 | Cincinnati | 13 | 108 | 110 | 23 | 241 | 18.5 |
| 9 | Temple | 3 | 26 | 27 | 6 | 59 | 19.7 |
| 10 | East Carolina | 7 | 62 | 69 | 9 | 140 | 20.0 |
| 11 | Memphis | 6 | 55 | 74 | 8 | 137 | 22.8 |