2021 American Athletic Conference Leaders Opponent First Downs - Games vs. FBS Teams With Winning Record Only through 01/10/2022
| Name | G | Rush | Pass | Penalty | Total | Total/G | |
|---|---|---|---|---|---|---|---|
| 1 | Houston | 5 | 23 | 45 | 11 | 79 | 15.8 |
| 2 | Navy | 10 | 72 | 94 | 13 | 179 | 17.9 |
| 3 | East Carolina | 6 | 48 | 59 | 10 | 117 | 19.5 |
| 4 | Cincinnati | 8 | 72 | 73 | 14 | 159 | 19.9 |
| 5 | SMU | 4 | 29 | 48 | 7 | 84 | 21.0 |
| 6 | Tulsa | 5 | 43 | 56 | 7 | 106 | 21.2 |
| 7 | Memphis | 7 | 76 | 76 | 8 | 160 | 22.9 |
| 8 | Temple | 5 | 50 | 61 | 8 | 119 | 23.8 |
| 9 | Tulane | 9 | 86 | 114 | 16 | 216 | 24.0 |
| 10 | UCF | 4 | 38 | 52 | 7 | 97 | 24.3 |
| 11 | South Florida | 8 | 89 | 108 | 14 | 211 | 26.4 |