2021 American Athletic Conference Leaders Opponent First Downs - Games vs. Ranked Teams Only (AP Poll) through 01/10/2022
| Name | G | Rush | Pass | Penalty | Total | Total/G | |
|---|---|---|---|---|---|---|---|
| 1 | Houston | 1 | 5 | 8 | 1 | 14 | 14.0 |
| 2 | East Carolina | 2 | 11 | 22 | 3 | 36 | 18.0 |
| 3 | Navy | 3 | 22 | 29 | 4 | 55 | 18.3 |
| 4 | Tulsa | 4 | 33 | 44 | 6 | 83 | 20.8 |
| 5 | Cincinnati | 3 | 26 | 38 | 4 | 68 | 22.7 |
| 6 | UCF | 1 | 15 | 6 | 2 | 23 | 23.0 |
| 7 | SMU | 2 | 16 | 30 | 1 | 47 | 23.5 |
| 7 | Temple | 2 | 20 | 26 | 1 | 47 | 23.5 |
| 9 | Memphis | 1 | 12 | 11 | 2 | 25 | 25.0 |
| 10 | Tulane | 4 | 43 | 51 | 7 | 101 | 25.3 |
| 11 | South Florida | 4 | 40 | 60 | 8 | 108 | 27.0 |