2021 American Athletic Conference Leaders Total Defense - Games vs. FBS Teams With Winning Record Only through 01/10/2022
| Name | G | Rush Yards | Pass Yards | Plays | Total Yards | Yards/Play | Yards/G | |
|---|---|---|---|---|---|---|---|---|
| 1 | Cincinnati | 8 | 1279 | 1392 | 577 | 2671 | 4.63 | 333.9 |
| 2 | Houston | 5 | 518 | 1262 | 297 | 1780 | 5.99 | 356.0 |
| 3 | Navy | 10 | 1288 | 2305 | 600 | 3593 | 5.99 | 359.3 |
| 4 | Tulsa | 5 | 826 | 1191 | 337 | 2017 | 5.99 | 403.4 |
| 5 | Memphis | 7 | 1147 | 1718 | 533 | 2865 | 5.38 | 409.3 |
| 6 | East Carolina | 6 | 934 | 1581 | 397 | 2515 | 6.34 | 419.2 |
| 7 | SMU | 4 | 581 | 1160 | 281 | 1741 | 6.20 | 435.3 |
| 8 | UCF | 4 | 738 | 1012 | 295 | 1750 | 5.93 | 437.5 |
| 9 | Tulane | 9 | 1678 | 2561 | 674 | 4239 | 6.29 | 471.0 |
| 10 | Temple | 5 | 1157 | 1222 | 349 | 2379 | 6.82 | 475.8 |
| 11 | South Florida | 8 | 1754 | 2115 | 568 | 3869 | 6.81 | 483.6 |