2021 American Athletic Conference Leaders Total Defense - Games vs. Unranked Teams Only (AP Poll) through 01/10/2022
| Name | G | Rush Yards | Pass Yards | Plays | Total Yards | Yards/Play | Yards/G | |
|---|---|---|---|---|---|---|---|---|
| 1 | Houston | 13 | 1305 | 2526 | 813 | 3831 | 4.71 | 294.7 |
| 2 | Cincinnati | 11 | 1617 | 1681 | 774 | 3298 | 4.26 | 299.8 |
| 3 | Navy | 9 | 1200 | 1905 | 522 | 3105 | 5.95 | 345.0 |
| 4 | Tulsa | 9 | 1138 | 2064 | 631 | 3202 | 5.07 | 355.8 |
| 5 | UCF | 12 | 1734 | 2591 | 881 | 4325 | 4.91 | 360.4 |
| 6 | Temple | 10 | 2150 | 1643 | 715 | 3793 | 5.30 | 379.3 |
| 7 | SMU | 10 | 1324 | 2630 | 695 | 3954 | 5.69 | 395.4 |
| 8 | East Carolina | 10 | 1710 | 2312 | 661 | 4022 | 6.08 | 402.2 |
| 9 | Tulane | 8 | 1142 | 2091 | 583 | 3233 | 5.55 | 404.1 |
| 10 | Memphis | 11 | 1808 | 2747 | 855 | 4555 | 5.33 | 414.1 |
| 11 | South Florida | 8 | 1588 | 1934 | 552 | 3522 | 6.38 | 440.3 |