2021 American Athletic Conference Leaders Total Defense - Games vs. FBS Teams With Non-Winning Record Only through 01/10/2022
| Name | G | Rush Yards | Pass Yards | Plays | Total Yards | Yards/Play | Yards/G | |
|---|---|---|---|---|---|---|---|---|
| 1 | Houston | 8 | 944 | 1405 | 515 | 2349 | 4.56 | 293.6 |
| 2 | Navy | 2 | 284 | 313 | 96 | 597 | 6.22 | 298.5 |
| 3 | Cincinnati | 5 | 716 | 828 | 353 | 1544 | 4.37 | 308.8 |
| 4 | East Carolina | 5 | 875 | 811 | 293 | 1686 | 5.75 | 337.2 |
| 5 | Tulsa | 7 | 943 | 1455 | 466 | 2398 | 5.15 | 342.6 |
| 6 | Tulane | 2 | 179 | 510 | 152 | 689 | 4.53 | 344.5 |
| 7 | UCF | 8 | 1308 | 1464 | 586 | 2772 | 4.73 | 346.5 |
| 8 | Temple | 6 | 1366 | 877 | 454 | 2243 | 4.94 | 373.8 |
| 9 | SMU | 7 | 951 | 1964 | 497 | 2915 | 5.87 | 416.4 |
| 10 | Memphis | 4 | 758 | 1094 | 330 | 1852 | 5.61 | 463.0 |
| 11 | South Florida | 3 | 601 | 797 | 163 | 1398 | 8.58 | 466.0 |