2021 American Athletic Conference Leaders Total Defense - Games vs. FBS non-Power 5 Conference Teams Only through 01/10/2022
| Name | G | Rush Yards | Pass Yards | Plays | Total Yards | Yards/Play | Yards/G | |
|---|---|---|---|---|---|---|---|---|
| 1 | Cincinnati | 11 | 1542 | 1815 | 778 | 3357 | 4.31 | 305.2 |
| 2 | Houston | 11 | 1192 | 2209 | 694 | 3401 | 4.90 | 309.2 |
| 3 | Navy | 12 | 1572 | 2618 | 696 | 4190 | 6.02 | 349.2 |
| 4 | Tulsa | 10 | 1310 | 2288 | 668 | 3598 | 5.39 | 359.8 |
| 5 | UCF | 10 | 1650 | 1995 | 738 | 3645 | 4.94 | 364.5 |
| 6 | East Carolina | 10 | 1710 | 2167 | 627 | 3877 | 6.18 | 387.7 |
| 7 | SMU | 10 | 1362 | 2848 | 720 | 4210 | 5.85 | 421.0 |
| 8 | Tulane | 9 | 1369 | 2422 | 657 | 3791 | 5.77 | 421.2 |
| 9 | Memphis | 10 | 1856 | 2393 | 780 | 4249 | 5.45 | 424.9 |
| 10 | Temple | 9 | 2124 | 1895 | 670 | 4019 | 6.00 | 446.6 |
| 11 | South Florida | 9 | 1699 | 2377 | 596 | 4076 | 6.84 | 452.9 |