2021 American Athletic Conference Leaders Total Defense - Games vs. FBS (I-A) Teams Only through 01/10/2022
| Name | G | Rush Yards | Pass Yards | Plays | Total Yards | Yards/Play | Yards/G | |
|---|---|---|---|---|---|---|---|---|
| 1 | Houston | 13 | 1462 | 2667 | 812 | 4129 | 5.08 | 317.6 |
| 2 | Cincinnati | 13 | 1995 | 2220 | 930 | 4215 | 4.53 | 324.2 |
| 3 | Navy | 12 | 1572 | 2618 | 696 | 4190 | 6.02 | 349.2 |
| 4 | Tulsa | 12 | 1769 | 2646 | 803 | 4415 | 5.50 | 367.9 |
| 5 | UCF | 12 | 2046 | 2476 | 881 | 4522 | 5.13 | 376.8 |
| 6 | East Carolina | 11 | 1809 | 2392 | 690 | 4201 | 6.09 | 381.9 |
| 7 | Temple | 11 | 2523 | 2099 | 803 | 4622 | 5.76 | 420.2 |
| 8 | SMU | 11 | 1532 | 3124 | 778 | 4656 | 5.98 | 423.3 |
| 9 | Memphis | 11 | 1905 | 2812 | 863 | 4717 | 5.47 | 428.8 |
| 10 | Tulane | 11 | 1857 | 3071 | 826 | 4928 | 5.97 | 448.0 |
| 11 | South Florida | 11 | 2355 | 2912 | 731 | 5267 | 7.21 | 478.8 |